After a bomb explosion devastates a residential apartment building, special agents Maggie Bell and Omar Adom “OA” Zidan of the New York office of the Federal Bureau of Investigation investigate a possible war between rival gangs – that is, until their prime suspects are discovered brutally murdered.

After eight people are fatally poisoned at a deli in New York City, special agents Maggie Bell and OA Zidan trace the crime to an unlikely culprit and conduct a sting operation to prevent further attacks.

Special Agent Maggie Bell, Special Agent OA Zidan and the team investigate the murders of 18 young women with help from a survivor associated with the deceased.

Special Agents Maggie Bell and OA Zidan rush to track down an active sniper with an elusive motive as the body count continues to rise.

Special Agents Maggie Bell and OA Zidan investigate the death of a safety inspector and its possible connection to a leak at a nuclear power plant.

After a senator’s daughter is kidnapped and held for ransom, the FBI is called in to assist with finding the child before their time limit expires. However, in order to do so, they must dig into the senator’s past for clues to who did this to his family.

Maggie and OA hunt down a ruthless group of robbers who are posing as police officers to target armored trucks.

Maggie and OA lead the search for an abducted former biological weapons chemist.

After a key witness and a U.S. marshal are ambushed and killed, Maggie and OA must track down a man who leaked the information that led to their murders.

When an illegal arms broker turned informant is assassinated, OA assumes his identity and goes undercover to stop the sale of dangerous weapons, with help from Maggie and their former FBI instructor, Rowan Quinn.

After a bomb detonates at a restaurant in Queens, the case becomes personal for OA, who grew up eating there. But what initially seems like a terrorist attack reveals itself to be more complex, and OA goes undercover to prevent another incident.

After the son of a prominent Mommy blogger is kidnapped, the team must sweep through her two million followers to find the culprit. Kristen continues to adjust to life as a field agent with her new partner.

After a front-running female presidential candidate, Valerie Caldwell, is targeted with a car bomb, OA and Maggie must hurry to track down the bomber before they strike again. The case leads them to wonder whether this person is targeting Caldwell for her political aspirations or something else.

After a shooting at a nightclub, it appears that the FBI may have ignored previous threats from a local white supremacist group. Also, Kristen wrestles with her commitment to the Bureau and her responsibility to her community.

A loving husband and father of two, Jim Russo, is kidnapped after accidentally getting involved in illegal dealings far beyond what he imagined. Also, Jubal must make a difficult decision regarding his family and their future.

After a Wall Street investor is murdered, the team is led to an insider-trading ring that uses unconventional methods to gain information. OA struggles to maintain confidence in his budding relationship with Mona.

When a board member of a soon-to-be-public medical tech company is murdered, the team tries to find out who had the most to gain from his death. OA is conflicted when pressure to help a family member is at odds with his commitment to tell the truth.

A car crash results in the death of a photographer; Maggie sympathizes with his widow when she notices similarities with her own husband's death.

After an altercation with a student, a teacher goes missing, leading the team to investigate everyone who might have had a grudge against him. Also, a key witness in the case steps up to help, and Maggie does whatever she can to ensure their safety.

A former kidnapping victim is linked to a series of murders that includes the daughter of an NYPD detective. Also, Kristen begins to doubt her ability as an agent after a training exercise leaves her shaken.

The team welcomes a new member, Special Agent Tiffany Wallace, as they search for killers who orchestrated a mass shooting at a media company, and OA’s personal connection with the case threatens to cloud his judgement.

The team races to stop an active serial killer after three women are found weighted down at the bottom of a lake, and Jubal looks into an old closed case after there are multiple similarities to the recent victims.

When the leader of a drug cartel and one of the world's most wanted men, Antonio Vargas, is apprehended by the team, the entire FBI headquarters is put at risk when his henchmen unveil a terroristic threat to free him. During the turmoil, Isobel must make the difficult decision whether to sacrifice her conscience or her career.

A shooting at a quinceañera leaves two dead, but the team believes they may not have been the intended targets. Also, Maggie is trapped between a rock and a hard place as the team decides the best plan of action for using a witness to take down the suspect.

As the team searches for a young girl who was kidnapped from a cabin during a family vacation, they discover that the abduction may be tied to a skeleton in her family's closet. Also, Maggie questions her relationship with Nestor when she learns he hasn't been completely honest with her.

The team must infiltrate a drug trafficking gang after the robbery of a chemical plant leaves two customs agents dead. Also, Nestor offers his help on the case, giving Maggie new insight into his character.

As the team hunts a killer who is fatally shooting seemingly unrelated targets, an experience on the job has new agent Tiffany Wallace examining the tension between her career as an FBI special agent and the responsibility she feels to her community as a Black woman.

After a bomb leaves three people dead, the team presses a reluctant informant to gather information from his close friends who are under suspicion. Also, OA finds tension in his relationship with his girlfriend, Mona, when they clash on where the informant’s rights lie.

When a political reporter is kidnapped and held without a ransom demand, the team must dig into her past relationships in order to pin down her assailant’s motive. Also, Isobel’s relationship comes under fire when the case makes a connection to her boyfriend, Ethan.

The team must track down two assailants who wear animal masks while committing armed robberies, with the latest leaving an off-duty 26 Fed security guard dead. Also, Tiffany and Scola butt heads on whether or not to accept the local NYPD’s offer to help in the investigation.

After a young woman is killed on her way home from a lavish yacht party, the team investigates who she was and how she came to be at the event, which was attended by some of the most influential people in the world. Also, Maggie brings Crosby into the investigation after a murder suspect is identified as a veteran who had been on several Army operations with Crosby. The crossover continues on FBI: Most Wanted S03E01 Exposed (II) and FBI: International S01E01 Pilot (III).

Maggie, OA and the team must stop a hacker who is disabling life-saving equipment in several New York City hospitals. Jubal's son waits for important surgery at one of the impacted hospitals.

The team finds a connection between bombings and a private veterans' club in New York City; Isobel tells a reluctant OA to recruit a former Army buddy for intel.

The team hunts for a serial killer who is targeting young, homeless men. Also, Tiffany and Scola don’t see eye to eye on how to handle the case or the difference between partners and co-workers.

After a suburban woman is kidnapped from her home, the team looks into trysts on both sides of a seemingly perfect marriage. Also, OA feels pressure from Mona to make changes in his career path.

The team must track down a shooter targeting detectives from the same precinct and unit, while facing mounting tension from the NYPD. Also, Tiffany finds that her NYPD roots may be influencing her view of the situation.

After a young girl is kidnapped from her daycare, the team must help her parents navigate a debt owed to the deadly gang in their neighborhood; Maggie struggles to focus on the case when her sister returns from rehab.

The team attempts to extract key information from a vulnerable 9/11 widow, Hannah Thompson, who is shocked that her new “boyfriend” is the manipulative leader of a terrorist group planning an attack. Also, Scola is reminded of his brother’s death on 9/11, and Tiffany worries about his emotional choices during the investigation.

After Rina is critically wounded while heading to work with Jubal, the team makes the chilling discovery that a vengeful Vargas orchestrated the shooting from behind bars and continues to target the rest of their team and their loved ones.

As the team investigates a string of jewellery store robberies that culminate in a double murder, they uncover a connection to a 16-year-old boy trying to survive the foster care system. Tiffany becomes personally invested after learning about the boy's ill-fated upbringing.

The team pivots when their sting operation to secure a massive bomb from an illegal broker leads them to discover that the device is already in the wrong hands. Also, Jubal’s promise to be present at his son’s birthday party is put to the test as the case continues to heat up.

When an officer is shot dead at a pawn shop along with the store’s owner, the team tries to figure out why a young, recent Ivy League dropout is tied to the crime.

As the team investigates a deadly robbery that garnered a cache of automatic weapons for the killers, they discover one of the perps is a classmate of Jubal’s son, who is reluctant to cooperate with the case.

The team investigates a series of brutal assaults; OA hides information about his own mugging.

When a wealthy accountant is gunned down for secretly testifying against a notorious drug lord, the team’s investigation leads Tiffany to ask for help from a friend who was formerly with the NYPD and is related to the dangerous crime boss.

As the team works to rescue a 5-year-old kidnapping victim, Scola suspects the boy’s mother isn’t being forthcoming about why her son was targeted. Also, Nina struggles to open up to Scola about matters in their relationship.

Maggie returns from medical leave in time to help the team investigate two homicides: a law student on track to attend the FBI Academy and a young man with possible gang ties. Also, an inadvertent revelation from Maggie causes OA to worry that she is rushing back into the job too quickly.

When a deadly truck heist arms the killers with enough ammonium nitrate to construct a massive bomb, the team discovers a link to a terrorist group Maggie is working to infiltrate.

A teen shows up at FBI headquarters with a large bag of fentanyl, seeking the team's protection from the men who shot his father; Nina goes to Scola with a proposal he is hesitant to accept.

The abduction of a young woman leads the team back to a cold case from 18 years ago, which pushes Isobel to reconnect with her old partner Jake and take another shot at solving one of her first cases in the bureau.

When a bus explosion kills several innocent people, the team jumps into action to take down the responsible terrorist organization. Meanwhile, Scola tries to balance fatherhood with the job.

After the president of the NY Fed is gunned down trying to help a young woman in peril, the team races to find the killer and the missing woman. Additionally, a distressing connection to one of Jubal’s past cases is revealed during the investigation, compounding the pressure on him as he also deals with his son’s school suspension.

When a local club owner is found dead, the team works quickly to find the motive behind the murder of a seemingly innocent man. Meanwhile, OA is smitten with a new love interest but is concerned that she's mixed up with the wrong crowd.

When a federal judge is gunned down execution-style in broad daylight, the team is sent looking for a suspect with ties to a local Islamic center. Also, Maggie reunites with a former colleague while things become tense between OA and his girlfriend Gemma.

When the director of a Brooklyn migrant center is abducted and held hostage along with his wife, the team must work quickly to meet the demands of their kidnapper. Also, Maggie picks Jessica's brain about motherhood.

After multiple people are targeted and killed with a poisonous gas in broad daylight, the team races to find the killer, who they believe is tied to an eco-terrorist plot. Meanwhile, Maggie continues to explore motherhood.

When a bombing at a local restaurant leaves several injured or dead, including a congresswoman and someone close to Isobel, the team races to apprehend the suspect before another explosive goes off.

After an employee of the U.S. Army is shot in an industrial park, the team works to track down the killer who reveals a larger plot at play. Meanwhile, Tiffany continues to struggle with the guilt surrounding Hobbs' death.

When a retired FBI agent is tortured and killed while working a security job, Scola and Nina go undercover as a married couple deep in the diamond game as the team tries to find out who is responsible. During the course of his and Nina's dangerous assignment, Scola is plagued by the possibility that their son Doug could end up parentless.

After an FDIC security guard is killed while tending to a pregnant woman in distress, the team works to locate the woman and the killer who took her hostage. Meanwhile, OA and Isobel worry about Maggie as she navigates taking care of Ella.

The assassination of a seemingly ordinary Brooklyn plumber launches the team into a globe-spanning investigation that ruffles feathers with the CIA.

The team is on the case when a suburban couple is murdered and all forensic evidence points to the home's previous owner, who is currently serving 10 years in federal prison.

After a series of targeted bombings in Queens, the team fears a citywide gang war is imminent – until a tip from OA's old Army buddy, Clay, directs their attention to an unexpected and powerful foe. Meanwhile, Scola continues to struggle to find a new partner.

When the sister of Sydney Ortiz is the victim of an attempted kidnapping and sexual assault, Sydney seeks help from Isobel and the team in tracking down a meticulous serial offender who leaves no evidence behind.

When a chaotic campus protest turns deadly, the team is called in to help quell the mayhem and track down the murderer. Meanwhile, Jubal is concerned when Tyler is detained along with a group of student protestors.

The team is called in to track down a serial killer after the bodies of multiple women with the same physical description are found scattered across the city. Meanwhile, Maggie juggles her roles as a guardian to Ella and an FBI agent.

After a park ranger is shot dead by a masked assailant on Governors Island, the team discovers a string of connected crimes that leads them to their toughest roadblock yet: an online conspiracy theory community.

After three customs officers are shot dead in a cargo heist, the team entrusts OA's old army buddy Clay to help determine if it was an inside job.

The investigation into an assistant U.S. attorney’s death leads the team to a related airline whistleblower scandal and the chilling discovery that they don’t have much time to thwart terrorists from crashing numerous in-flight commercial airplanes. Dealing with the memory of his brother, who was a 9/11 victim, the case pushes Scola hard to prevent another catastrophe.

Jubal's longtime confidential informant brings intel of an impending large-scale terror attack to the team, but when the details don't add up, Jubal must sift out the truth from a man who's known him at his worst.

After a federal judge disappears, a routine investigation takes a dark turn as the team uncovers that the judge had been searching for his missing son on a secluded island on the city's edge, where authority has crumbled. Meanwhile, reality weighs heavy on Jubal as he takes on a new leadership role.

When paintings from a high-profile international cultural exchange are stolen – leaving a security guard dead – the team races to recover the priceless artworks. Meanwhile, Maggie turns to a friend for help profiling suspects.

After a young man is found beaten to death on federal land, Scola and Special Agent Eva Ramos hit a roadblock when their case intersects with a DEA operation. Meanwhile, there is a potential shake-up inside of the JOC.

Following a failed assassination attempt on a U.S. Senator, OA and Maggie are tasked with escorting her back to DC on a flight that becomes more perilous than imagined.