Several thousand years after a mysterious phenomenon turns all of humanity to stone, the extraordinarily intelligent, science-driven boy, Senku Ishigami, awakens from petrification. Facing a world of stone and the total collapse of civilization, Senku makes up his mind to use science to rebuild the world. Starting with his super strong childhood friend Taiju Oki, who awakened at the same time, they will begin to rebuild civilization from nothing. Depicting two million years of scientific history from the Stone Age to present day, the unprecedented crafting adventure story is about to begin.

Facing immediate danger from wild animals Senku and Taiju are forced to revive Tsukasa Shishio "The Strongest High School Primate". Although Tsukasa has tremendous fighting ability and provides abundant food as their hunter, their new ally harbors an opposing view on restoring humanity.

Senku does not trust the motivation of Shishio, so he will try to hide his plans from a new and unforeseen enemy for his plan to revive civilization.

Senku has the idea of ​​creating gunpowder to have a way to balance the scale and have a chance to defeat Shishio. The production of gunpowder causes a fire. Shortly thereafter, Senku and the others discover smoke signals on the horizon. An accident? Hardly likely. Apparently there are other people in the stone world ...

Shishio is determined to end Senku's life if he does not promise at that moment that he will abandon his idea of ​​recovering civilization as it was before the incident.

Taiju and Yuzuriha figure out Senku's secret to reviving him. But now that he's back, they need to deal with Tsukasa.

Kohaku shows Senku to her village, but it's going to take some convincing before they let him in. In the meantime, he makes friends with a like-minded, promising "sorcerer."

Kohaku's sister, village priestess Ruri, is gravely ill. Senku, Chrome and Kohaku begin their quest to make antibiotics to save her life.

Senku starts a ramen stand in hopes of winning over support for his kingdom of science, but some people are too principled to take such a bribe. Mentalist Asagiri Gen is not one of them.

Senku and his kingdom of science successfully test the first lightbulb since the collapse. Meanwhile, Asagiri Gen, a spy from Tsukasa's empire, is killed by an unknown attacker.

Senku continues in trying to advance the Stone World, this time he makes "space food", it is in actuality cup noodles. After Senku finishes his project, Gen has an epiphany and devises a plan to take down Tsukasa's army without violence.

While Senku's diversion buys Gen and others some time, soon Homura realizes something is not right.

Taiju and Yuzuriha are on the verge of tears after they hear Senku's voice, and Senku informs them of his plan to win the war without any bloodshed.

Chrome and Magma struggle with Ukyo, while Senku, gets his hands busy with building up an invention; a new hope.

The final touches to the automobile are made and it is used to transport the science supplies to a fortified cliffside that's close to the Tsukasa empire. From there the automobile is upgraded into a tank, but unbeknownst to the rescue group preparations by the empire have been made to counter any vehicular attack.

Chrome must use all of his scientific knowledge to escape from his prison and save Senku and others.

Senku decides to use the Steam-Gorilla to capture The Miracle Cave. Using Lillian's recording, Senku gains the trust of more of Tsukasa's men. Ukyo reveals he saw Yuzuriha's secret mission to reassemble the fragments of statues Tsukasa destroyed.

The Final Battle for the miracle cave starts as Senku and the Kingdom of Science conduct a frontal assault on the cave.

Tsukasa and Hyoga are coming to capture the miracle cave. The Kingdom of Science must buy Senku and Chrome some time to turn the tide, or it is all over.

Senku demands a truce from Tsukasa in return for reviving his sister, Mirai, who Tsukasa comes to know is alive, but a new problem shows up when Hyoga shows his true self.

While continuing to use the hot air balloon to search for the oil, it's decided that Ishigami Village needs to take up agriculture to prevent future food shortages, as well as to produce preserved food for their upcoming sea voyage.

The Kingdom of Science will need rations to last them through their voyage to the other side of the world. But Senku, being no professional, burns all the bread he attempts to bake.

Senku, brings along a team to look for the Sagara Oil Fields. Meanwhile, Suika and Francois go truffle hunting.

The morse code signal reading "WHY" saturates the airwaves too much for Ukyo to pinpoint a direction, so the Kingdom of Science works on a way to visualize the signal.

Kaseki's efforts to build the science vessel Perseus hit a roadblock when he realizes that it's impossible to get all the parts to fit in practice.

The Perseus crew are on their way to the treasure island, the birthplace of the Hundred Tales, where they hope to locate the treasure box left behind by the Soyuz crew.

The Perseus arrives at the treasure island. A recon squad consisting of Senku, Soyuz, Kohaku, and Gen set off to locate the platinum and make contact with the islanders. Ukyo later discovers something on the seafloor and send Ginro to investigate.

Amaryllis explains how she evaded petrification and how she came to her decision to sneak into the inner palace.

Suika and Ginro work together to rescue the mobile lab from the Perseus. Reunited with Senku and the others, the group works on items to help Kohaku with the selection process.

Amaryllis, Ginro and Kohaku are chosen to join the inner palace. The science team will need a way to communicate with them in secret, and, eventually, a way for them with the science team.

Senku and his companions finally set off for America in search of corn. However, a dispute arises between Ryusui and Senku shortly after they depart.

Maintaining morale will be critical on the long journey to the Americas. Knowing where on the ocean you are is pretty important, too. The crew of the Perseus discuss.

The Perseus lands in the Americas. They first head to Northern California in search of yellow dent corn, but discover a lot more than that.

The search party narrowly escaped enemy machine gun fire. Unfortunately, the respite was short-lived.

Tensions rise as Dr. Xeno makes his introductions to the Perseus.

Stanley orders Luna to infiltrate the Perseus and identify Doctor Taiju. Things go sideways when it turns out to be a little too easy.

Senku had gotten his start in rocket building through an email exchange with Doctor Xeno. Their approaches to science soon diverged.

NASA scientist Dr. Xeno attempts to pick off the leader of the Kingdom of Science.

With Senku having been shot, the Kingdom of Science plots its retaliation against Dr. Xeno.

With Senku still confined to the bed, Chrome's team begins work on the tunnel to Xeno's base.